This study showed that we were able to develop a saturated double W/O/W emulsion. Multiple emulsions designed as drug delivery systems would be significant in the controlled release of oral, topical, or parenteral administrations when the stability and release mechanisms can be more clearly understood and monitored. The dye test and the conductivity measurement confirmed the W/O nature of the emulsion and W/O/W nature of the double emulsion. Multiple emulsions are complex polydispersed systems where both oil in water and water in oil emulsion. The stability of these emulsions has been studied using several parameters (pH, conductivity, droplet size, dye test). Swami Vivekanand College of Pharmacy, Indore (M.P.). The emulsification was carried out using a rotor stator mixer. The Bancroft rule served as a model for the formulation. It is possible to make very simple calibrated emulsions of controlled size, exploiting a phenomenon called "limited coalescence". These systems are experiencing renewed interest on the one hand, because it is preferable to limit the use of synthetic surfactants for ecological reasons, and on the other hand, because the functionalization of particles has undergone recent advances.
The continuous phase contains the emulsifier, which helps stabilize the globules in the dispersed phase. Pickering emulsions are surfactant-free emulsions, stabilized by colloidal particles. Oil-in-water emulsions are used with hydrophilic emulsifiers like sodium lauryl sulfate, sodium oleate, triethanolamine stearate, and glyceryl monostearate and when the aqueous phase constitutes more than 45 of the total weight. To overcome these difficulties, a two-stage emulsification strategy has been developed, first generating a water-in-oil Pickering emulsion stabilized by magnesium oxide particles and then the double W/O/W emulsion, thereby reducing significantly the amount of voltage-active. There are two problems that hinder the use of double emulsions in pharmacies: large-scale equipment not available for one-step emulsification and obtaining a double emulsion and limited ingredients available to replace the tension-active agents as primary emulsifier because these surfactants are toxic. But some times, emulsions are the formulation of choice to mask the taste of a very bitter drug or when the oral solubility or bioavailability of a drug is to.
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